Studies

*Someday I hope to create a searchable database but, until then, I want to have the resources available as is. You can search this page to find studies from a specific year, name, or topic. The list and links will be updated frequently.

M83DM - Development of mefloquine as an antimalarial drug

-UNDP, World Bank, WHO Update

-Bulletin of the World Health Organization

-1983

-https://apps.who.int/iris/bitstream/handle/10665/264887/PMC2536124.pdf?sequence=1&isAllowed=y 


M83PC - A phase II clinical trial of mefloquine in patients with chloroquine-resistant falciparum malaria in Thailand

-

-World Health Organization

-1983

-https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2536127/pdf/bullwho00098-0127.pdf 


M85TM - Trials of Mefloquine in Vivax and of Mefloquine plus ‘Fansidar’ in Falciparum Malaria (abstract)

-T Harinasuta, R Lasserre, D Bunnag, R Leimer, S Vinijanont

-The Lancet

-1985

-https://pubmed.ncbi.nlm.nih.gov/2858743/ 


M89AE - Adverse Effects of the Antimalarial Drug Mefloquine

-PHA Information Exchange System ALERT

-World Health Organization (WHO)

-1989

-https://cdn.who.int/media/docs/default-source/pvg/drug-alerts/da002---drug_alert2adverse_effects_of_mefloquine.pdf?sfvrsn=4f00c0ac_4 


M89AP - Acute Psychosis After Mefloquine (ScienceDirect access needed)

-P. C. Stuiver, R. J. Ligthelm, Th. J. L. M. Goud

-Department of Tropical Medicine, Havenziekenhuis, Netherlands

-1989

-https://pubmed.ncbi.nlm.nih.gov/2569094/ 


M89MA - Mefloquine and an Acute Brain Syndrome (excerpt)

-B Rouveix, F Bricaire, C Michon, G Franssen, J Lebras, C Bernard, J Bernard, F Ajana, J L Vienne

-Presse medicale

-1989

-https://www.acpjournals.org/doi/10.7326/0003-4819-110-7-577?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed 


M91NM - Navy Medical Department Guide to Malaria Prevention and Control

-Navy Environmental Health Center

-1991


M91PA - Panic Attack After Therapeutic Administration of Mefloquine (Abstract)

-De Gennes C, Colas C, Nollet D, et al.

-Annales de la Medicine Interne (Paris)

-1991


M94CA - Central Anticholinergic Syndrome with the Antimalarial Drug Mefloquine

-Rudolf Speich, M.D., Alois Haller, M.D.

-University Hospital of Zurich

-1994

-https://www.nejm.org/doi/pdf/10.1056/NEJM199407073310120?articleTools=true 


E95MG -Mefloquine-induced grand mal seizure during malaria chemoprophylaxis in a non-epileptic subject (abstract)

-E. Pous, J. Gascón, J. Obach, M. Corachan

-Infectious Disease Department (Tropical Diseases Unit), Neurology Department, Hospital Clinic, Barcelona, Spain

-1995

-https://academic.oup.com/trstmh/article-abstract/89/4/434/1913699?redirectedFrom=fulltext 


M95MT - Mefloquine toxicity should limit its use to treatment alone 

-G C Cook

-Hospital for Tropical Diseases, London

-1995

-https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2550242/ 


M96CA - Comparison of adverse events associated with use of mefloquine and combination of chloroquine and proguanil as antimalarial prophylaxis: postal and telephone survey of travellers

-P J Barrett, P D Emmins, P D Clarke, D J Bradley

-Medical Advisory Services for Travellers Abroad, London

and London School of Hygiene and Tropical Medicine

-1996

-https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2351944/ 


M96NC - Neurological, cardiovascular and metabolic effects of mefloquine in healthy volunteers: a 

double-blind, placebo-controlled trial

-Timothy M. E. Davis, Lawrence G. Dembo, Sally A. Kaye-Eddie, Benjamin J. Hewitt, Robert G. Hislop, and Kevin T. Batty

-University of Western Australia, Department of Medicine, Fremantle Hospital

-1996

-https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2125.1996.tb00003.x 


M97CS - Case Study: Neuropsychiatric Symptoms Associated With the Antimalarial Agent Mefloquine (abstract)

-Richard N. Clattenburg, Craig L Donnelly

-Journal of the American Academy of Child & Adolescent Psychiatry

-1997

-https://www.jaacap.org/article/S0890-8567(09)66572-2/pdf 


M97SP - Stereoselective Passage of Mefloquine Through the Blood-Brain Barrier in the Rat

-S. Baudry, Y. T. Pham, B. Baune, S. Vidrequin, Ch. Crevoisier, F. Gimenez, R. Farinotti

-Département de Pharmacie Clinique, Chatenay-Malabry, France

-1997

-https://academic.oup.com/jpp/article/49/11/1086/6152901?login=false 


E98MG - Mefloquine-induced grand mal seizure in tubercular meningitis (abstract)

-Bregani ER, Tien TV, Figini G

-Panminerva Med.

-1998

-https://pubmed.ncbi.nlm.nih.gov/9973835/ 


M98UC - A Unique Case of Mefloquine-induced Psoriasis

-Israel Potasman and Hanna Seligmann

-Bnai Zion Medical Center, J Travel Med

-1998

-https://academic.oup.com/jtm/article/5/3/156/1821138?login=false 


M99AP - Acute paranoid hallucinatory psychosis following mefloquine prophylaxis (Lariam) (Abstract)

- Kruger, Grube, Hartwich

-Psychiatrische Praxis

-1999

-https://pubmed.ncbi.nlm.nih.gov/10535096/ 


M99EM - Epidemiology of Malaria in the British Army from 1982-1996

-Miller, Bergman, Croft

- J R Army Med Corps

-1999

-https://militaryhealth.bmj.com/content/145/1/20.long 


E00SA - Seizures after Antimalarial Medication in Previously Healthy Persons

-Ricarda Schiemann, Jean P. Coulaud, and Olivier Bouchaud

-Department of Infectious Diseases and Tropical Medicine, Bichat-Claude Bernard Hospital, Paris Cedex 18, France

-2000

-https://academic.oup.com/jtm/article/7/3/155/1795732


M01AM - Atovaquone-Proquanil versus Mefloquine for Malaria Prophylaxis in Nonimmune Travelers: Refults from a Randomized, Double-Blind Study

-David Overbosch, Herbert Schilthuis, Ulrich Bienzle, Ronald H Behrens, Kevin C Kain, Paul D Clark, Stephen Toovey, Jurgen Knobloch, Hans Dieter Nothdurft, Dea Shaw, Neil S Roskell, Jeffrey D Chulay, Malarone International Study Team

- Tropical Medicine and Tuberculosis UK, Infectious Diseases Society of America

-2001

-https://academic.oup.com/cid/article/33/7/1015/428605?login=false 


M01CN - Cognitive and Neuropsychiatric Side Effects of Mefloquine

-Debbie J Javorsky, Geoffrey Tremont, Gabor I Keitner, A Hilton Parmentier

- Department of Psychiatry and Human Behavior , Brown University School of Medicine, Providence, RI

-2001

-https://neuro.psychiatryonline.org/doi/epdf/10.1176/jnp.13.2.302 


E02MC - Mefloquine: contraindicated in patients with mood, psychotic or seizure disorders

-Eric Wooltorton

-CMAJ (Canadian Medical Association Journal)

-2002

-https://www.ncbi.nlm.nih.gov/pmc/articles/PMC134297/pdf/20021112s00024p1147.pdf 


M02UF - Unexpected frequency, duration and spectrum of adverse events after therapeutic dose of mefloquine in healthy adults

-Pamela Rendi-Wagner, Harald Noedl, Walther H. Wernsdorfer, Gerhard Wiedermann, Andrea Mikolasek, Herwig Kollaritsch

- Acta Tropica

-2002

-https://www.sciencedirect.com/science/article/abs/pii/S0001706X01002108?via%3Dihub 


M03ES - Effect of sample size and P-value filtering techniques on the detection of transcriptional changes induced in rat neuroblastoma (NG108) cells by mefloquine

-Geoffrey S Dow

- WRAIR

-2003

-https://www.ncbi.nlm.nih.gov/pmc/articles/PMC152658/pdf/1475-2875-2-4.pdf 


M03TM - Tolerability of malaria chemoprophylaxis in non-immune travellers to sub-Saharan Africa; multicentre, randomised, double blind, four arm study

-Patricia Schlagenhauf, Alois Tschopp, Richard Johnson, Hans D Nothdurft, Bernhard Beck, Eli Schwartz, Markus Herold, Bjarne Krebs, Olivia Veit, Regina Allwinn, Robert Steffen

- Acambis, Cambridge, United Kingdom

-2003

-https://www.ncbi.nlm.nih.gov/pmc/articles/PMC261741/pdf/bmj32701078.pdf 


M04AP - The Antimalarial Potential of 4-Quinolinecarbinolamines May Be Limited due to Neurotoxicity and 

Cross-Resistance in Mefloquine-Resistant Plasmodium falciparum Strains

-Geoffrey S Dow, Michael L Koenig, Lesley Wolf, Lucia Gerena, Miriam Lopez-Sanchez, Thomas H Hudson, Apurba K Bhattacharjee

- Divisions of Experimental Therapeutics and Neurosciences (WRAIR)

-2004

-http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC434181&blobtype=pdf 


M05MI - Mefloquine Induces Dose-Related Neurological Effects in a Rat Model

-G. Dow, R. Bauman, D. Caridha, M. Cabezas, F. Du, R. Gomez-Lobo, M. Park, K. Smith, and K. Cannard

-Divisions of Experimental Therapeutics, Military Casualty Research, Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Maryland

-2005

-https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1426433/ 


M06KS - Keeping Score on Psychiatric Drug Effects: Is Mefloquine Safe for Malaria Chemoprophylaxis (Abstract)

-Catherine B Willmore, Linda W Ayesu

-J Pharm Technol

-2006

-https://journals.sagepub.com/doi/abs/10.1177/875512250602200106 


M06PP - Psychosis with paranoid delusions after a therapeutic dose of Mefloquine

-Tuan M Tran, Joseph Browning, Mary L Dell

-Malaria Journal, Emory University School of Medicine, Department of Psychiatry

-2006

-https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1564027/pdf/1475-2875-5-74.pdf 


M08PC - Prevalence of contraindications to mefloquine use among USA military personnel deployed to Afghanistan

-Remington L Nevin, Paul P Pietrusiak, Jennifer B Caci

-Malaria Journal

-2008

-https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2259366/pdf/1475-2875-7-30.pdf 


E09EP - Epileptogenic potential of mefloquine chemoprophylaxis: A pathogenic hypothesis

-Remington Nevin

-The Quinism Foundation

-2009

-https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736201/ 


M09MI - Mefloquine induces oxidative stress and neurodegeneration in primary rat cortical neurons

-Jonathan E Hood, Jerry W Jenkins, Dejan Milatovic, Lu Rongzhu, Michael Aschner

-CFD Research Corporation, HudsonAlpha Institute for Biotechnology, Alabama; Department of Pediatrics, Division Of Clinical Pharmacology Toxicology , Vanderbilt University Medical Center; Department of Preventive Medicine, Jiangsu University, China

-2009

-https://www.researchgate.net/profile/Rongzhu-Lu/publication/44686650_Mefloquine_induces_oxidative_stress_and_neurodegeneration_in_primary_rat_cortical_neurons/links/5b0529780f7e9b24a2af6e2c/Mefloquine-induces-oxidative-stress-and-neurodegeneration-in-primary-rat-cortical-neurons.pdf 


M10AM - Anti-malaria drug mefloquine induces motor learning deficits in humans

-Thomas A van Essen, Ruben S van der Giessen, Sebastiaan K E Koekkoek, Frans VanderWerf, Chris I DeZeeuw, Perry J J van Genderen, David Overbosch, Marcel T G de Jeu

-Kucers’ The Use of Antibiotics, Volume 1, 6th Edition

-2010

-https://www.frontiersin.org/articles/10.3389/fnins.2010.00191/full 


M10RD - Randomized, Double-Blind Study of the Safety, Tolerability, and Efficacy of Tafenoquine versus Mefloquine for Malaria Prophylaxis in Nonimmune Subjects

-Peter E Nasveld, Michael D Edstein, Mark Reid, Leonard Brennan, Ivor E Harris, Scott J Kitchener, Peter A Leggat, Philip Pickford, Caron Kerr, Colin Ohrt, William Prescott, Tafenoquine Study Team

-Australian Army Malaria Institute; GlaxoSmithKline Research & Development Limited; Division of Experimental Therapeutics, WRAIR; US Army Medical Materiel Development Activity; Centre for Military and Veterans’ Health, University of Queensland

-2010

-https://journals.asm.org/doi/epub/10.1128/aac.00354-09 


M10CR - A Clinical Review of Antibacterial, Antifungal, Antiparasitic and Antiviral Drugs - Mefloquine

-Geoffrey S Dow, Alan J Magill

-Kucers’ The Use of Antibiotics, Volume 1, 6th Edition

-2010


M11LE - Limbic encephalopathy and central vestibulopathy caused by mefloquine: A case report (Preview)

-Remington L Nevin

-Bayne-Jones Army Community Hospital, LA

-2011

-https://www.sciencedirect.com/science/article/abs/pii/S1477893912000336?via%3Dihub 


M11ME - Mefloquine effects on VTA Dopamine neuron sIPSC frequency, amplitude, and interevent interval

-David W Allison, Rebecca S Wilcox, Kyle L Ellefsen, Caitlin E Askew, David M Hansen, Jeffrey D Wilcox, Stephanie S Sandoval, Dennis L Eggett, Yuchio Yanagawa, and Scott C Steffensen

-Brigham Young University; Synapse (journal)

-2011

-? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056588/pdf/nihms-495050.pdf 


M11SN - Severe Neuropsychiatric Reaction in a Deployed Military Member after Prophylactic Mefloquine

-Alan L Peterson, Robert A Seegmiller, Libby S Schindler

- Department of Psychiatry, University of Texas Health Science Center; 59th Medical Operations Squadron, Wilford Hall Medical Center

-2011

-https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420400/pdf/CRIM.PSYCHIATRY2011-350417.pdf 


E13ET - Epilepsy triggered by mefloquine in an adult traveler to Uganda

-Federico Gobbi, Andrea Rossanese, Dora Buonfrate, Andrea Angheben, Chiara Postiglione, and Zeno Bisoffi

-Department of Tropical Diseases, Sacro Cuore-Don Calabria  Hospital, Italy

-2013

-https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920231/pdf/wjcc-2-12.pdf 


M13HG - Hippocampal Glial Degenerative Potentials of Mefloquine and Artequin in Adult Wistar Rats

-Nsikan-Abasi B Udoh, Theresa B Ekanem, Moses B Ekong, Aniekan I Peter, Amabe O Akpantah

-Department of Anatomy, University of Uyo, Nigeria; Department of Anatomy, University of Calabar, Nigeria

-2013

-https://www.hindawi.com/journals/ijbs/2014/104785/ 


M13PS - Psychiatric Side Effects of Mefloquine: Applications to Forensic Psychiatry

-Elspeth Cameron Ritchie, Jerald Block and Remington Lee Nevin

-Department of Mental Health, DC, Department of Rural Mental Health, Veterans Affairs Medical Center, PDX, Department of Mental Health, Johns Hopkins

-2013

-https://jaapl.org/content/jaapl/41/2/224.full.pdf 


M14IQ - Idiosyncratic quinoline central nervous system toxicity: Historical insights into the chronic neurological sequelae of mefloquine

-Remington L. Nevin

-Department of Mental Health, Johns Hopkins Bloomberg School of Public Health

-2014

-www.ncbi.nlm.nih.gov/pmc/articles/PMC4095041/pdf/main.pdf 


M14KA - Knowledge, Attitudes, and Practices Regarding Antimalarial Chemoprophylaxis in U.S. Peace Corps Volunteers – Africa, 2013

-Keren Z. Landman, Kathrine R. Tan, Paul M. Arguin

-Morbidity and Mortality Weekly Report

-2014

-https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779364/pdf/516-517.pdf 


M14UP - Updated PRAC rapporteur assessment report on the signal of permanent neurologic (vestibular) disorders with mefloquine

-Pharmacovigilance Risk Assessment Committee (PRAC) 

-European Medicines Agency

-2014

-https://www.calameo.com/read/0059833808a97906d2061 


M14RC - Risk of Compliance: Tracing Safety and Efficacy in Mef-Lariam’s Licensure

-Julie Marie Gerdes  - Graduate Theses and Dissertations

-University of South Florida

-2014

-digitalcommons.usf.edu/cgi/viewcontent.cgi?article=6418&context=etd 


M15CM - Complex Membrane Channel Blockade: A Unifying Hypothesis for the Prodromal and Acute Neuropsychiatric Sequelae Resulting from Exposure to the Antimalarial Drug Mefloquine

-Jane C Quinn

-Plant and Animal Toxicology Group, School of Animal and Veterinary Sciences, Graham Centre for Agricultural Innovation, Charles Sturt University, Australia

-2015

-https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630403/pdf/JPR2015-368064.pdf 


M15MP - Mefloquine Prophylaxis as a cause of Suicide and Chronic Neuropsychiatric Illness: Mismanagement and Neglect in the Australian Defence Force

-Major Stuart McCarthy

-Submission to Senate Foreign Affairs, Defence and Trade References Committee Inquiry into the Mental Health of Australian Defence Force Serving Personnel

-2015

-https://www.aph.gov.au/DocumentStore.ashx?id=b0b7be32-1d41-445b-8210-c949953c0568&subId=353818


M16MA - Mefloquine-associated dizziness, diplopia, and central serous chorioretinopathy: a case report

-Manish Jain , Remington L. Nevin, Iajaz Ahmed

-Journal of Medical Case Reports, Department of Environmental Health Engineering, Johns Hopkins Bloomberg School of Public Health 

-2016

-https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088661/pdf/13256_2016_Article_1091.pdf 


M16MN - Mefloquine in the nucleus accumbens promotes social avoidance and anxiety-like behavior in mice

-Mitra Heshmati, Ph.D., Sam A. Golden, Ph.D., Madeline L. Pfau, Daniel J. Christoffel, Ph.D., Elena L. Seeley, Michael E. Cahill, Ph.D., Lena A. Khibnik, Ph.D., and Scott J. Russo, Ph.D.

-Fishberg Department of Neuroscience and Friedman Brain Institute Graduate School of Biomedical Sciences at the Icahn School of Medicine at Mount Sinai, New York

-2016

-https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681593/pdf/nihms734354.pdf 


M16NA - Neuropsychiatric Adverse Reactions to Mefloquine: a Systematic Comparison of Prescribing and Patient Safety Guidance in the US, UK, Ireland, Australia, New Zealand, and Canada

-Remington L. Nevin, Aricia M. Byrd

-Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Trinity School of Medicine

-2016

-https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919134/pdf/40120_2016_Article_45.pdf 


M17PC- Pannexin-1 channel dysfunction in the medial prefrontal cortex mediates depressive-like behaviors induced by chronic social defeat stress and administration of mefloquine in mice

-Ming Ni, Jin-Gang He, Hai-Yun Zhou, Xiao-Jia Lu, Yuan-Lang Hu, Li Mao, Fang Wang, Jian-Guo Chen, Zhuang-Li Hu

-Huazhong University, China; The Key Laboratory of Neurological Diseases (HUST), China; The Institute of Brain Research, China; The Collaborative-Innovation Center for Brain Science, China; The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province, China

-2017

-https://www.researchgate.net/publication/344761079_Pannexin-1_channel_dysfunction_in_the_medial_prefrontal_cortex_mediates_depressive-like_behaviors_in_mice


M18ML- Mefloquine Long Half-Life is Associated with Sustained Psychiatric Side Effects: A Case Report

-Eric Constant, Emmanuel Hermans, Pierre Wallemacq, Arnaud Capron

- Department of Adult Psychiatry, Department of Clinical Chemistry, Institute of Neurosciences, Group of Neuropharmacology, Clinical and Forensic Toxicology, Catholic University of Leuven, Belgium; 

-2018

-https://neuropsychiatry.imedpub.com/mefloquine-long-halflife-is-associated-with-sustained-psychiatric-side-effects-a-case-report.pdf 


M20MB- Mefloquine binding to human acyl-CoA binding protein leads to redox stress-mediated apoptotic death of human neuroblastoma cells (Preview)

- Abhishek Kumar, Debasish Kumar Ghosh, Akash Ranjan

- Centre for DNA Fingerprinting and Diagnostics, India; Manipal Academy of Higher Education, India 

-2020

-https://www.sciencedirect.com/science/article/abs/pii/S0161813X20300140?via%3Dihub 


M20PS- Psychiatric Side Effects of Chloroquine

-Florence Gressier, Celine Verstuyft, Laurent Becquemont, Bruno Falissard, Emmanuelle Corruble 

-Department Psychiatry Bicetre University Hospital, France; MOODS team, Universite Paris-Saclay; Molecular Genetics, Pharmacogenetics and Hormonology Department, Paris-Saclay University Hospitals; Department of Biostatistics, Universite Paris-Saclay

-2020

-https://www.psychiatrist.com/jcp/schizophrenia/side-effects/psychiatric-side-effects-of-chloroquine/ 


M21WR- Differential Stabilities of Mefloquine Bound Human and Plasmodium falciparum Acyl-CoA-Binding Proteins

-Abhishek Kumar, Debasish Kumar Ghosh, Akash Ranjan

-Computational and Functional Genomics Group, Centre for DNA Fingerprinting and Diagnostics, India; Department of Biotechnology, Govt. of India

-2021

-https://pubs.acs.org/doi/10.1021/acsomega.0c04582 


M21WR- Walter Reed Army Institute of Research (WRAIR): Fifty Years of Achievements That Impact Science and Society

-COL Carl R. Alving, MC, USA (Ret.)

-Military Medical History

-2021

-https://academic.oup.com/milmed/article/186/3-4/72/6031606